In recent years, Thiophene and its derivatives have known an increasing importance as intermediates to biologically active compounds and in organic synthesis . 2-Amino-3-functionally substituted thiophene derivatives have been studied as probe molecules in chemical biology and drugs or hits in medicinal chemistry . They are also used as precursors in the azo dye and pharmaceutic industries . 2-aminothiophene is a central five-membered heterocyclic core that is prepared using Gewald methodology , which known several modifications to target a wide range of substrate. The use of inorganic bases like sodium bicarbonate, sodium hydroxide , sodium carbonate instead of morpholine, pyridine, triethylamine , Organic reactions in heterogeneous phase . All of them seemed advantageous over conventional systems. The presence of the two active sites CN and NH₂ in 2-Amino-3-cyano substituted thiophene derivatives offers a multitude of interesting reactions such as the preparation of tetrazole derivatives very well-known by their exceptional properties; a large number of nitrogen atoms, good stability, acidity and basicity in addition to several properties in medicinal, biological and material sciences . Tetrazole derivatives are known for their molecular fluorescence. Our laboratory interested in the development and functionalization of heterocyclic compounds with promising biological and pharmacological activities including some new concept of green chemistry ; as a part of our research, different types of 2-aminothiophenes were achieved in good yields that are then used to prepare tertazole derivatives.