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Semisynthesis of 6β-acetoxyvouacapane derivates via the Ugi-azide multicomponent reaction
1, 2 , 3 , 4 , 4 , 2 , 2 , * 2 , * 3
1  laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58030, Morelia, Michoacán, México
2  laboratorio de Productos Naturales, Instituto de Investigaciones Químico Biológicas, Universidad Michoaca-na de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58030, Morelia, Michoacán, México
3  laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58033, Morelia, Michoacán, México
4  Instituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Ingeniería Campus Guanajuato, Av. Mineral de Valenciana 200 Col. Fracc. Industrial Puerto Interior, Silao 36275, Guanajuato, Mexico
Academic Editor: Julio A. Seijas

Abstract:

A semisynthesis of 6β-acetoxyvouacapane-1,5-disusbtituted tetrazoles derivates from the leaves of Caesalpinia platyloba by using the Ugi-azide multicomponent reaction as a key step reaction is described. To our knowledge, this is the first report where a non-natural product such as 1,5-disusbtituted tetrazole is linked to a natural product or derivate of a natural product, and beyond the biological relevance that the target molecules present, this work contributes to the area of natural products as well as multicomponent reactions

Keywords: 6β-acetoxyvouacapane; 1,5-disusbtituted tetrazoles; Ugi-azide; isocyanides; semisynthesis
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