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Synthesis of bis-amides employing a plant-derived triterpenoid as component in the Ugi reaction
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Academic Editor: Julio A. Seijas
Published:
14 November 2022
by MDPI
in The 26th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
Herein we describe the synthesis of a series of four novel triterpenoid-derived bis-amides employing masticadienonic acid from Pistacia mexicana, as carboxylic acid component in the Ugi reaction. Products were obtained via a facile and efficient one-pot procedure, under mild green conditions, with moderate yields (29-58%). The stereo-electronic nature of the aldehyde component influences the reaction yields.
Keywords: Ugi reaction (U-4CR); isocyanide-based multicomponent reaction (I-MCR); bis-amide; triterpenoid
