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A green isocyanide based multicomponent click reactions for the synthesis of 1-substituted 1H-1,2,3,4-tetrazoles
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Academic Editor: Julio A. Seijas
Published:
14 November 2022
by MDPI
in The 26th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
https://doi.org/10.3390/ecsoc-26-13570
(registering DOI)
Abstract:
A series of five 1-substituted-1H-1,2,3,4-tetrazoles were synthesized via a novel isocyanide based multicomponent click reaction (IMCCR) under solvent, catalyst and column-free conditions at room temperature. This new, green and sustainable IMCCR methodology resulted in good to excellent yields(76–88%).
Keywords: green synthesis; 1-substituted 1H-1,2,3,4-tetrazoles; isocyanide-based multicomponent reactions (I-MCR).
