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A green isocyanide based multicomponent click reactions for the synthesis of 1-substituted 1H-1,2,3,4-tetrazoles
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1  Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química
Academic Editor: Julio A. Seijas (registering DOI)

A series of five 1-substituted-1H-1,2,3,4-tetrazoles were synthesized via a novel isocyanide based multicomponent click reaction (IMCCR) under solvent, catalyst and column-free conditions at room temperature. This new, green and sustainable IMCCR methodology resulted in good to excellent yields(76–88%).

Keywords: green synthesis; 1-substituted 1H-1,2,3,4-tetrazoles; isocyanide-based multicomponent reactions (I-MCR).