Synthesis of carbazolyl imidazo[1,2- &alpha;] pyridines via Groebke-Blackburn-Bienayme reaction under green catalyst

¹ Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato 36050, Mexico
² Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM. Carretera Toluca-Atlacomulco Km 14.5, Universidad Autónoma del Estado de México, Toluca, Estado de México, 50200, México
³ Facultad de Química, Universidad Autónoma del Estado de México. Paseo Colón esq. Paseo Tollocan, 50120, Toluca, Mexico

Academic Editor: Julio A. Seijas

Published: 14 November 2022 by MDPI in The 26th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-26-13575 (registering DOI)

Abstract:

Multicomponent reactions (MCR) are efficient and versatile synthetic tools, they also have several advantages such as high convergence, operational simplicity, atomic economy, friendly conditions, and MCR products are obtained with good to excellent overall yields. The Groebke-Blackburn-Bienaymé (GBB) multicomponent reaction based on isonitriles (MCR-I) in the synthesis of imidazo[1,2-α]pyridines (IMP) under green catalyst like montmorillonite K-10 has been little reported. Therefore, the present work describes the novel ultrasound-assisted one-pot synthesis for analogs of imidazo[1,2-α] pyridines (IMPs) incorporating the carbazole.

Keywords: Green synthesis; Imidazo[1,2-α]pyridines (IMP); Isocyanide-based multicomponent reactions (I-MCR)

View paper

20 Reads
0 Recommendations

Alejandro Corona-Díaz

Mahanandaiah Kurva

M.V. Basavanag Unnamatla

Gustavo Rangel Porras

Rocío Gámez-Montaño