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Synthesis of carbazolyl imidazo[1,2- α] pyridines via Groebke-Blackburn-Bienayme reaction under green catalyst
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Gustavo Rangel Porras
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Academic Editor: Julio A. Seijas
Published:
14 November 2022
by MDPI
in The 26th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
https://doi.org/10.3390/ecsoc-26-13575
(registering DOI)
Abstract:
Multicomponent reactions (MCR) are efficient and versatile synthetic tools, they also have several advantages such as high convergence, operational simplicity, atomic economy, friendly conditions, and MCR products are obtained with good to excellent overall yields. The Groebke-Blackburn-Bienaymé (GBB) multicomponent reaction based on isonitriles (MCR-I) in the synthesis of imidazo[1,2-α]pyridines (IMP) under green catalyst like montmorillonite K-10 has been little reported. Therefore, the present work describes the novel ultrasound-assisted one-pot synthesis for analogs of imidazo[1,2-α] pyridines (IMPs) incorporating the carbazole.
Keywords: Green synthesis; Imidazo[1,2-α]pyridines (IMP); Isocyanide-based multicomponent reactions (I-MCR)
Gustavo Rangel Porras
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