Eugenol, a natural phenolic allyl benzene, have been used as active lead compound showing significant biological activities, namely as antimicrobial, antifungal and insecticidal on a wide variety of domestic arthropod pests.

Owing to the negative ambient impact and public health problems of synthetic conventional insecticides, less harmful alternatives are required in order to circumvent these inconveniences.

Considering these facts, in the present work ester eugenol derivatives were synthesized and evaluated for their insecticidal activities against the Spodoptera frugiperda cell line. Studies of structured-based inverted virtual screening were carried out in order to identify the potential targets associated to the obtained insecticidal activity.