Several studies have shown that the pyrano[3,2-c]chronenes moiety is a source of several molecules possessing interesting and considerable biological activities on the medicinal level, notably antimicrobial, anti-inflammatory, analgesic and anti-anxiolytic, anticancer activity. The main objective of this work is to evaluate the antioxidant and antimicrobial activities of pyrano[3,2-c]chronenes by using classical methods and more developed techniques.

Two series of pyrano[3,2-c]chromene derivatives have been prepared by synthetic and catalyst means, with an excellent yield which ranges between (90-96)% and then characterized via infrared and NMR analysis techniques.

The antioxidant activity was assessed using the DPPH method and by the power of iron reduction. The determination of antimicrobial activity was carried out against the reference bacteria.

The results of the antioxidant activity showed that both families of pyrano[3,2-c]chromenes have a reduction in DPPH radical and iron. While these families havea good antibacterial effect with inhibition areas ranging from 8 to 12 mm.

The results of antioxidant activity showed that both families of pyrano[3,2-c]chromenes showed a reduction in DPPH radical and iron. While these families have a good antibacterial effect with inhibtion areas ranging from 8 to 12 mm.