In this research, the three-component synthesis of quinazoline derivatives with various substitutions has been investigated using a new chitosan-based catalyst grafted by 5-sulfosalicylic acid under green chemistry conditions. FT-IR, NMR, XRD, EDX, VSM, and FESEM spectroscopic, microscopic or analytical methods were used for characterization of the new catalyst as well as identification of quinazoline derivatives. The obtained results show significant catalytic activity of the supramolecular nanocatalyst for the expeditious and efficient synthesis of 2,3-dihydroquinazoline-4(1H)-one derivatives, as an important pharmaceutical scaffold, via a three-component one-pot condensation of isotonic anhydride and aromatic aldehydes with amine sources.
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Preparation and characterization of 5-sulfosalicylic acid grafted to a chitosan-based support for the synthesis of quinazoline derivatives under green chemistry conditions
Published:
17 November 2022
by MDPI
in The 26th International Electronic Conference on Synthetic Organic Chemistry
session Polymer and Supramolecular Chemistry
https://doi.org/10.3390/ecsoc-26-13678
(registering DOI)
Abstract:
Keywords: Multicomponent reactions (MCRs), Green and sustainable chemistry, Modified chitosan nanomaterials, Quinazoline derivatives, Solid acid catalyst.
