The clearness of the cornea is essential for visual acuity and is guaranteed by limbal stem cell regeneration of the outer specialized epithelium and by the integrity of the inner corneal endothelium.

Limbal Stem Cell Deficiency (LSCD) leads to multiple corneal abnormalities including visual loss. Autologous Cultivated Limbal Stem Cell Transplantation is the first stem cell treatment for LSCD, approved at EU level. Here we present the results from the first EU multicenter clinical trial on EU citizens and a following step for the future restoration of other corneal areas, specifically the corneal endothelium.