The progressive spread of antibiotic-resistant microorganisms is a public health problem, so
the search for new substances with antimicrobial properties has been growing over the years, especially
natural products. Triterpenes are widely distributed in the plant kingdom and have several
pharmacological activities described. Studies involving the stereochemistry of drugs greatly contribute
to the choice of the isomer that is more active and that promotes fewer adverse effects for humans. The
α,β-amyrin isomers in their isolated form may have different or even similar pharmacological properties,
but with different intensities of activity due to the change in the position of the methyl groups that
influence bioactivity. From the studies previously carried out, it was seen that both have antibacterial
activity against S. aureus when they are separated or mixed, leading to the conclusion that there is no
need to separate these two, because the migration of the C-29 methyl does not influence in this type of
activity.
We have a question for you, you can read and answer bellow.
Question for Authors:
Are there and/or are you planning studies on synthesis, characterization, and biological testing of derivatives of these compounds?
REVIEWWWERS'23 participation:
We also invite you to participate in the REVIEWWWERS Workshop, which is now open, by making questions to other authors.
The steps are very easy. instructions: Step(1), Register/Login here [Register/Login] to Sciforum platform. Step(2), Go to presetations list [MOL2NET'23 Papers List], Step(3), Scroll down papers list and click on one title. Step(4), Scroll down and click on Commenting button, post your comment, and click submit. Step(5), Repeat review process for other papers. Step(6), Request certificate. See details [Reviewers Workshop] or contact us at Email: mol2net.chair@gmail.com.
Sincerely yours
MOL2NET Team
What specific observations or findings suggest that there is no need to separate these isomers for antibacterial activity?
