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Retinoic acid isomers as promising molecules against Alzheimer's disease
1 , 1 , 1 , 1 , 1 , 1 , 1 , 1, 2 , * 1
1  Postgraduate Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, Castelo Branco - João Pessoa - Brazil
2  Teaching and Research Management - University Hospital, Federal University of Paraíba, João Pessoa, PB, Brazil
Academic Editor: Humbert G. Díaz

https://doi.org/10.3390/mol2net-09-14116 (registering DOI)
Abstract:

Alzheimer's is a neurodegenerative and
irreversible disease. In Alzheimer's disease, it is
possible to identify the presence of insoluble
amyloid β deposits in plaques in the brain.
Retinoic acid isomers are being studied as a new
alternative for Alzheimer's disease. In this work,
the isomers are analyzed: all-trans retinoic acid,
9-cis retinoic acid and 13-cis retinoic acid. They
may play an important role in AD by protecting
neurons from β-amyloid-induced cell death.

Keywords: Chemical; pharmacochemistry; chemoinformatics
Comments on this paper
Shan He
How do the isomers of retinoic acid, specifically all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, demonstrate potential in protecting neurons from β-amyloid-induced cell death in the context of Alzheimer's disease, and what mechanisms underlie their neuroprotective effects?

Harbil Bediaga
I find this a very interesting topic. Looking at the literature that has been used, what could be the next steps to study these compounds?



 
 
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