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Retinoic acid isomers as promising molecules against Alzheimer's disease
Jessica P De Moura
1
,
1
,
Igor MA De Araujo
1
,
Nikole D Trigueiro
1
,
Paulo SDS Pereira
1
,
1
,
Marcus Tullius Scotti
1
,
Luciana Scotti
1, 2
,
Alex France Messias Monteiro
*
1
Academic Editor: Humbert G. Díaz
Published:
05 March 2023
by MDPI
in MOL2NET'23, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 9th ed.
congress CHEMBIO.MOL-09: Org. Chem., Med. Chem., Mol. Biol., & Pharm. Industry Congress, Paris, France-Fargo, USA, 2023.
https://doi.org/10.3390/mol2net-09-14116
(registering DOI)
Abstract:
Alzheimer's is a neurodegenerative and
irreversible disease. In Alzheimer's disease, it is
possible to identify the presence of insoluble
amyloid β deposits in plaques in the brain.
Retinoic acid isomers are being studied as a new
alternative for Alzheimer's disease. In this work,
the isomers are analyzed: all-trans retinoic acid,
9-cis retinoic acid and 13-cis retinoic acid. They
may play an important role in AD by protecting
neurons from β-amyloid-induced cell death.
Keywords: Chemical; pharmacochemistry; chemoinformatics
Comments on this paper
Shan He
2 January 2024
How do the isomers of retinoic acid, specifically all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, demonstrate potential in protecting neurons from β-amyloid-induced cell death in the context of Alzheimer's disease, and what mechanisms underlie their neuroprotective effects?
Harbil Bediaga
23 January 2024
I find this a very interesting topic. Looking at the literature that has been used, what could be the next steps to study these compounds?
Jessica De Moura
,
Igor De Araujo
,
Nikole Trigueiro
,
Paulo Pereira
,
Marcus Scotti
,
Luciana Scotti
,
Alex Monteiro
