HIV-human immunodeficiency virus is an infection caused by a virus that causes the progressive destruction of some white blood cells present in the blood, causing AIDS-acquired immunodeficiency syndrome. Calanolide A is a drug indicated for people with the AIDS-AIDS acquired immunodeficiency syndrome, in which it enables the inhibition of the HIV-protase of the virus in order to prevent the initial development of the virus until its maturation. Calanolide B is a compound present in C. cerasiferum, used as other agents in the therapy of the human immunodeficiency virus (HIV). In this study, the main objective was the study of spatial dispositions and their effects and activities based on the position in which Calanolides A and B are presented in the context of stereochemistry.