Abstract: Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with their nine subfamilies are classified by sequence similarity, resulting in this superfamily's tremendous physiological functional diversity. Because TRP channels also play essential roles in cellular signaling and allow the host cell to respond to benign or detrimental environmental changes, understanding how each TRP channel responds to its unique forms of activation energy is critical and crucial as its impairment may lead to several diseases, especially carcinogenesis. One of them is pancreatic cancer, one of the deadly types increasing in prevalence without adequate treatment. Scientific research has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. TRP channels have been reported to be associated with several cancers. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions.