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Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing unsubstituted lactam nitrogen and 2- chloro-8-arylthiomethyl were synthesized via efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.