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Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
1 , 1 , 2 , 3 , 4 , * 1, 4
1  Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand
2  Department of Chemistry, Faculty of Science, Ubonratchathani University, Ubonratchathani 34190, Thailand
3  Department of Microbiology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
4  Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10903, Thailand

Abstract: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing unsubstituted lactam nitrogen and 2- chloro-8-arylthiomethyl were synthesized via efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.
Keywords: n/a