Background: Polymeric nanoparticles are a promising substances for the delivery of therapeutics. Among polymeric nanoparticles, PLGA is famous because of its biodegradability, biocompatibility, stability, and sustained drug release. Poly(vinyl alcohol) and poloxamer188 are stabilizers and surfactants which are applied as nanoparticle stabilizers and targeting delivery agents, respectively. The benefits of herbal medicine in palliative therapy have been studied. Cinnamon extract has received a lot of attentions due to its significant properties such as antibacterial, antifungal, antioxidant, and even anti-cancer properties. The aim of this study was to prepare PLGA nanoparticles loaded with cinnamon extract and characterize their physiochemical properties and also their antioxidant and cytotoxicity against the C6 cell line.

Materials and methods: PLGA nanoparticles were prepared by the emulsion solvent evaporation technique. The mean diameter of nanoparticles was assayed using Dynamic Light Scattering, and Scanning Electron Microscopy. Zeta potential was measured as well. Drug loading and encapsulation efficiency were also performed. Antioxidant activity and also cytotoxicity of nanoparticles were assayed by DPPH and MTT, respectively.

Results: the mean diameter of nanoparticles was about 100 nm with the negative zeta potential. Drug loading and encapsulation efficiency were 4.2% and 51% respectively. The release profile of cinnamon extract from PLGA nanoparticles was extended until 5 days. The antioxidant activity of the cinnamon extract was partially preserved in nanoparticles and also the anticancer property of nanoparticles was confirmed via MTT assay.