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Antimicrobial evaluation of benzo[a]phenoxazine heterocycles: structure–activity relationships
Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: A series of functionalised 5,9-diaminobenzo[a]phenoxazinium salts, in the free form or linked to L-glycine and L-valine amino acids were evaluated against Saccharomyces cerevisiae, in a microdilution broth assay. The results obtained showed that these compounds exhibited antifungal activity depending on the substituents of the 5,9-diaminobenzo[a]phenoxazine nucleous. The best activities were obtained when substituents at the positions 9 and 10 were NHEt, and Me, respectively, and at the position 5, NH(CH2)3Cl or NH(CH2)3CO2Et.