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Evaluation of the ß-turn inducing properties of an achiral analogue of aminopiperidinone carboxylates
Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: cis-4-(Acetylamino)-N-methylcyclohexane carboxamide has been selected as all carbon ring analogue of the previously described 5-aminopiperidinone-2-carboxylate systems. The potential ß-turn inducing properties of this model compound are evaluated by means of NMR analysis and molecular modeling.
Keywords: ß-turn mimic, intramolecular hydrogen bridge, achiral, aminopiperidinone carboxylate