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Evaluation of the ß-turn inducing properties of an achiral analogue of aminopiperidinone carboxylates
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1  Molecular Design & Synthesis, Department of Chemistry, K.U.Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium

Abstract: cis-4-(Acetylamino)-N-methylcyclohexane carboxamide has been selected as all carbon ring analogue of the previously described 5-aminopiperidinone-2-carboxylate systems. The potential ß-turn inducing properties of this model compound are evaluated by means of NMR analysis and molecular modeling.
Keywords: ß-turn mimic, intramolecular hydrogen bridge, achiral, aminopiperidinone carboxylate