Please login first
Formulation of modified microspheres based on galactosylated lactic acid polymers
* 1 , 2 , 3
1  University of Balamand, Faculty of Sciences, P.O.Box :100-Tripoli, Lebanon
2  Laboratoire de Genie pharmaceutique UMR 5007 CNRS, Faculte de pharmacie, 8 avenue Rockfeller, 69373 Lyon cedex, France
3  UMR 5078 CNRS, Universit√© Claude Bernard, bat 305, 43bd du 11 Nov 1918.69622 Villeurbanne Cedex, France

Abstract: A new series of galactosyl-derived polymers has been used for the preparation of microspheres. The strategy is based on the modification of the terminal carboxylic group L-PLA by coupling to a galactosyl antenna in the presence of the peptide coupling agents : DCC/HOBT . the degree of functionalisation varies between 60 and 70%, and antenna density between 1.74 and 2.78. In an effort to develop a new way of drug delivery, especially for polymeric antifungal molecules, we have incorporated amphotericin B (AmB) into biodegradable galactosylated poly(L-lactic acid) L-PLA . These drug carriers were prepared by solvent evaporation method using an oil/water (o/w) emulsion. The ratio of galactosylated microspheres was 7.14 mg for L-PLA (encapsulation rate 45% of mole). In our yeast model, drug release depend on three factors : i) presence of galactosylated antennae, ii) length of galactosyl antenna and iii) nature of the polymer . These novel functionalized microspheres could be required for the delivering of therapeutic agents according to their recognition to specific cells .
Keywords: n/a