Propargylamines are interesting intermediates to synthesize built and heterocycled molecules  such as pyrrole, oxazoles, pyrazoles . Furthermore, a number of propargylamines derivatives were used to treat Parkinson’s and Alzheimer’s disease such as rasagyline . Their preparation method has drawn the attention of a significant number of researchers. In view of the synthetic procedure, the three coupling component of alkyne, aldehyde and amine (A3) was used in the presence of catalysts
In life science, the recent development of nanotechnology has introduced the potential of inorganic nanomaterials [5, 6]. copper phosphate catalyst have attracted considerable attention of researchers because of their electrochemical properties, compositional and good activity. This material CuPO4 is known as an electrode which are used as a novel high-capacity cathode , there are a wide variety of applications for phosphates of various transition metals including catalysis, environmental remediation, sensors, and electronic materials . Copper phosphate showed excellent performance for oxidation of aromatic benzyl compounds to aromatic ketones.
This work provides a new way to prepare copper phosphate efficient heterogeneous catalysts by hydrothermal route. The catalyst was characterized by FTIR, XRD, and Raman spectroscopy. The nanocatalysts showed a high activity in the propargylamines synthesis via the A3 coupling of aldehyde, amine and alkyne with high a yield .