Propargylamines are interesting intermediates to synthesize built and heterocycled molecules [1] such as pyrrole, oxazoles, pyrazoles [2]. Furthermore, a number of propargylamines derivatives were used to treat Parkinson’s and Alzheimer’s disease such as rasagyline [3]. Their preparation method has drawn the attention of a significant number of researchers. In view of the synthetic procedure, the three coupling component of alkyne, aldehyde and amine (A3) was used in the presence of catalysts[4]
In life science, the recent development of nanotechnology has introduced the potential of inorganic nanomaterials [5, 6]. copper phosphate catalyst have attracted considerable attention of researchers because of their electrochemical properties, compositional and good activity. This material CuPO4 is known as an electrode which are used as a novel high-capacity cathode [7], there are a wide variety of applications for phosphates of various transition metals including catalysis, environmental remediation, sensors, and electronic materials [8]. Copper phosphate showed excellent performance for oxidation of aromatic benzyl compounds to aromatic ketones.
This work provides a new way to prepare copper phosphate efficient heterogeneous catalysts by hydrothermal route. The catalyst was characterized by FTIR, XRD, and Raman spectroscopy. The nanocatalysts showed a high activity in the propargylamines synthesis via the A3 coupling of aldehyde, amine and alkyne with high a yield [9].
