Cissus quadrangularis is a common perennial succulent climber plant belongs to Vitaceae family. The plant is having strong pharmacological profile with variety of phytoconstituents and is being geographically distributed throughout tropical and subtropical regions of the world. Prominently found in India, Pakistan and Bangladesh. In India plant was found all over but dominantly in states namely Assam, Kerala, Odisha, Madhya Pradesh, Tamil Nadu, and Uttar Pradesh. The plant in India popularly called as ‘Hadjod’ or ‘Asthisamharaka’ and very well established as medicines related to management of bone, muscles and ligament issues. Traditionally almost all aerial well as underground parts are having medicinal value but stem is most commonly used. Phytochemicals studies performed on plant revealed the presence of variety of constituents viz Tannins, proteins, carbohydrate, phenol flavonoids, triterpenoids, phytosterols, glycosides, Saponins, vitamin C and alkaloids. Beside these plant is also a rich source of calcium. The systematic review had also established the pharmacological role of plant as bone setter and fractured bone healer, antimicrobial, anti-diabetic, anti-inflammatory, anti-obesity, anti-oxidant, bone turnover, cardiovascular and hepatoprotective and many more. The current review article had made the detailed discussion on it phytochemical and pharmacological potential.