Abstract

Diabetes mellitus (DM) is a common long-term illness characterized by elevated blood sugar. Diabetes makes wounds take longer to heal because of things like infection, poor blood flow, neuropathy, and an insufficient response to proliferative and cytokine signals. Recent research has shown that the majority of wound treatments that are currently on the market are not sufficient enough to meet patients' needs. With today's state-of-the-art nanotechnology, researchers have the potential to either completely reimagine and create brand-new therapeutic approaches or significantly improve the efficacy of existing ones. Nanodrug delivery systems, in particular, have emerged as a major player in the field of skin regeneration due to their ability to tether bioactive components to the targeted area, slow the drug's release, and dramatically enhance the therapeutic effects of medications. Manufactured agents from the field of nanotherapy, such as nanoparticles and nanoscafolds, have recently shown promise in the treatment of diabetic wounds. Nanoparticles used in medicine have a large surface area relative to their size. Because of this, they have a better chance of interacting with living things and entering wounds. They work wonderfully for the slow, localised delivery of drugs that stimulate cell-to-cell communication, proliferation, blood vessel formation, signalling, and biomolecule production during wound healing. One or more therapeutic medication molecules can be released into the intended site slowly over time by using nanoparticles. The promising results seen with nanoparticulate systems indicate that research into the technology's capabilities will expand in the near future, expanding nanotechnology's already substantial medical benefits. Focusing on chronic cutaneous wounds, we evaluate the viability and efficacy of the most recently developed nanotechnology-based medications. In this article, we scrutinize the unmet needs of the wound-healing field as well as the future directions of the technologies that are currently available, while also discussing novel approaches that can advance the field.