In several cultures, black cumin, also known as Nigella sativa, has long been used medicinally. Recent research has revealed that this plant has potent anti-inflammatory and antioxidant qualities, making it a possible treatment for several medical conditions. Additionally, because of its capacity to detoxify the liver and protect it from harm, Nigella sativa has demonstrated positive results as an antidote for poisoning. Consumption of hazardous substances by accident or planned poisoning are two prevalent causes of poisoning. The liver is the primary organ in detoxification. According to studies, nigella sativa can help the liver operate better and defend it from toxins' harmful effects. Additionally, it has been demonstrated that Nigella sativa protects against heavy metals toxicity. Thymoquinone and thymohydroquinone, the plant's active components, have been demonstrated to bond with heavy metals and stop the body from absorbing them. Further studies are needed to evaluate the efficacy and safety of Nigella sativa as an antidote for poisoning cases. Nigella sativa presents an interesting natural alternative for treating poisoning cases, potentially complementing traditional medical approaches. The main goal of this review is to explore the potential application of Nigella sativa as an antidote for poisoning cases. The article discusses the plant's strong ability to detoxify and protect the liver. The review highlights preclinical studies that have shown promising results but also emphasizes the need for further clinical trials to determine the efficacy and safety of Nigella sativa as a natural alternative for treating poisoning cases.