Heterocyclic compound of S and N with cyclic structure like Furans, thiophenes and related azole analogs are important as ligand because of readily available, stable and easily functionalized. Among the various types of heterocyclic molecules quinazolines and their derivatives contain important chromophores with desirable electrochemical properties to be applied for application in sensor field. Metal complexes of these compounds have demonstrated significant electrochemical properties as ionophore or electroactive material for the fabrication of ISEs with different polymeric membranes. R. Selva Kumar, et al.; 2019 reported the use of dibutyl(8-hydroxyquinolin-2-yl)methylphosphonate as ionophore in PVC metrix for the fabrication of potentiometric thorium(IV) ion-selective electrode [1]. These quinazoline based membranes with other additives and plasticizers are very useful for the development of potential difference across the membrane in electrochemical sensing devices in required proportions [2-4]. Analytes such as Butralin, Hydroxylamine, Nitrite, heavy metal ions like Fe3+, Th4+ have also been determined using quinazoline based membrane sensors. ISE based electrochemical sensors are very useful in analysis of food products, drinking water, beverages, fertilizers, soil industrial effluents etc. These alos finds application in potentiometric titrations as indicator electrode.