Sida linifolia L., is traditionally used in a number of diseased conditions including the relief of uncomfortable teething and the prevention of malaria. The aim of this study was to investigate the antioxidant and anti-inflammatory properties of Sida linifolia. For the in vitro anti-inflammatory tests, platelet aggregation, albumin denaturation, protease, and phospholipase A₂ were performed. Then for the in vivo studies of the same, egg albumin and carrageenan induced models were employed. The total antioxidant capacity (TAC), 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing power (FRAP), and nitric oxide (NO) assays were used in the in vitro antioxidant assessment, and the reference standards for the antioxidant tests were butylated hydroxytoluene (BHT), gallic acid, and ascorbic acid, whereas the anti-inflammatory studies employed aspirin and prednisolone as standards. Every parameter was calculated using conventional methods. In the fraction, there were varying concentrations of terpenoids, saponins, steroids, alkaloids, flavonoids, tannins, and other phenols. The EALFSL displayed robust, concentration-dependent anti-inflammatory effects, which were comparable to those of the reference drugs (Aspirin/Prednisolone). The EALFSL fraction's IC₅₀ values ranged from 0.93 to 1.20 mg/ml which was less active than those of BHT (0.30), ascorbic acid (0.32-0.50), and gallic acid (0.47). The outcomes additionally demonstrated that EALFSL has a significant level of concentration-dependent antioxidant activity. These suggest that the ethylacetate leaf fraction of Sida linifolia possessed anti-inflammatory and antioxidant effects which could be attributed to phytochemicals contained in it.