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Eco-Friendly Approach to Craft High-Demand Cyclic Carbonates for the Pharmaceutical Industry
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1  University of Catania
Academic Editor: Alfredo Berzal-Herranz (registering DOI)

Cyclic carbonates play a crucial and multifaceted role in the pharmaceutical industry due to their versatile properties and applications. They are essential intermediates in synthesizing various pharmaceutical compounds, making them indispensable in drug development. With an increasing focus on sustainable and environmentally friendly practices in the pharmaceutical sector, cyclic carbonates offer a greener alternative. They can be produced using more cycloaddition reactions of carbon dioxide to substitute epoxides, which represents an eco-friendly and economically viable procedure to form cyclic carbonates compared to traditional chemical processes, aligning with the industry’s sustainability goals.

This study investigates the development of a green and efficient catalytic process for synthesizing carbonates as pharmaceutical intermediates using carbon dioxide as a reagent. The heterogeneous catalyst employed in this research was designed and synthesized based on its environmentally benign characteristics, cost-effectiveness, and catalytic efficiency. This catalyst’s utilization minimizes the reaction's environmental impact and enhances the selectivity and yield of the interested products. The reaction mechanism and kinetics are elucidated to gain insight into the catalytic process. Furthermore, the production of cyclic carbonates as pharmaceutical precursors underscores its significance in synthesizing various drugs, providing a sustainable alternative to conventional methods.

This study highlights the importance of green chemistry principles in synthesizing valuable compounds like carbonates. Combining a heterogeneous catalyst with carbon dioxide as a renewable and abundant resource demonstrates the potential for sustainable chemical processes in the pharmaceutical industry.

Keywords: carbonate, catalyst, green, sustainable, drug