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In vitro DNA protective potential of Chamaecyparis lawsoniana (A.Murray bis) Parl. and Thuja plicata Donn ex D.Don essential oils
* 1 , 2 , 3 , 2
1  Department of Science, Institute for Information Technologies Kragujevac, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia
2  Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
3  Department of Genetics, Plant Breeding, Seed and Nursery Production, Institute of Forestry, Kneza Višeslava 3, 11000 Belgrade, Serbia
Academic Editor: Alfredo Berzal-Herranz

Published: 01 November 2023 by MDPI in 9th International Electronic Conference on Medicinal Chemistry session General (registering DOI)

Chamaecyparis lawsoniana (A.Murray bis) Parl., known as Port Orford cedar or Lawson cypress and Thuja plicata Donn ex D.Don, also called giant arborvitae, are a species of the Cupressaceae family. Multiple significant biological activities of C. lawsoniana and T. plicata essential oils have been widely investigated, but their genotoxic and/or antigenotoxic properties are not well established. In the present study, two in vitro antioxidant assays were performed to assess the possible DNA protective activity of five different concentrations (0.19, 0.38, 0.75, 1.5, and 3%) of essential oils against oxidative damage induced by hydroxyl and peroxyl radicals. According to the obtained results, both essential oils have a remarkable DNA protective activity against hydroxyl and peroxyl radicals induced DNA damage. These findings confirm that C. lawsoniana and T. plicata essential oils in tested concentrations could be valuable candidates for medicinal and pharmaceutical applications.

Keywords: Essential oils; Chamaecyparis lawsoniana; Thuja plicata, antigenotoxicity, hydroxyl radical, peroxyl radical