Please login first
"Exploring the Pharmacological Potential of Quinazolinone Derivatives: Antibacterial Efficacy "
* 1 , * 2
1  Department of Pharmaceutical Chemistry, LSHGCT's Gahlot Institute of Pharmacy, Plot no.59, Sector-14, Koperkhairane, Navi Mumbai, Maharashtra-400709
2  Department of Pharmaceutical Chemistry and Quality Assurance, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Gate No.1, Mithibai College Campus, Vaikunthlal Mehta Rd, Vile Parle West,Mumbai, Maharashtra-400056, India
Academic Editor: Maria Emília Sousa (registering DOI)

The research delves into quinazolinone derivatives, a significant class of heterocyclic compounds. With a resilient quinazolinone nucleus, these derivatives have been explored for their pharmacological potential. Computational docking studies reveal their promise as DNA gyrase inhibitors, with compound (Nitro substituent) displaying a notable -8.3 kcal/mol docking score. Binding energy analyses and receptor interactions highlight their potential . The study's core involves synthesizing Quinazolin-4(3H)-one derivatives with variations at the 6th position. NMR and IR spectral data confirm distinctive structural characteristics. These derivatives exhibit potent antimicrobial activity against gram-positive and gram-negative bacteria, including E. coli, S. typhi, B. subtilis, and S. aureus. Notably, nitro-substituted derivatives demonstrate substantial antibacterial efficacy, indicating a promising avenue for future antimicrobial drug development. Overall, the research underscores the diverse and promising applications of quinazolinone derivatives in pharmacology and therapeutic interventions.

Keywords: Quinazolinone derivatives, Antimicrobial activity, Docking study