Antibiotic resistance is one of the most serious threats to human health, food security and development today. New resistance mechanisms are emerging and spreading everywhere, threatening our ability to treat common infectious diseases. In this work, new semi-synthetic agents were synthesized based on a derivative of the natural compound Camphor, thiosemicarbazide and 2-acetyl/2-benzoylpyridine. For this purpose, thiosemicarbazones were synthesized in two steps. At the first step the N⁴-norbornylthiosemicarbazide was dissolved in ethanol with 2-acetylpyridine/2-benzoylpyridine. Concentrated hydrochloric acid was added to the obtained solution. At the second step the obtained 2-acetylpyridine hydrochloride N⁴-norbornylthiosemicarbazone (HL¹) and 2-benzoylpyridine hydrochloride N⁴-norbornylthiosemicarbazone (HL²) were dissolved in ethanol and neutralized with an aqueous solution of Na₂CO₃. Then extraction with chloroform was done. The resulting substances were studied using FT-IR and NMR ¹H, ¹³C spectroscopy. The copper(II) coordination compounds were obtained by reaction between HL¹ or HL² and copper(II) nitrate trihydrate, copper(II) chloride dihydrate, and copper(II) dicloroacetate. The complexes [Cu(L^1,2)X] (X = NO₃^- (I, VI), Cl^- (II, V), CHCl₂COO^- (III, VI)) were studied by elemental analysis, FT-IR spectroscopy and molar conductivity. The antibacterial activity against Gram-positive microorganisms: Staphylococcus aureus and Bacillus cereus was studied for the obtained substances. The results showed that 2-benzoylpyridine N⁴-norbornylthiosemicarbazone (HL²) is inactive one, and its copper(II) coordination compounds are 8 times less active than complexes with HL¹ against Staphylococcus aureus and 32 times less active against Bacillus cereus. They in many cases surpass the activity of Furacillinum and are practically on the same level as Tetracycline, that are used in medicine.