Medical cargo drones carry containers usually subjected to many external parameters such as temperature, pressure, humidity etc. Also, the drones carrying medical units flying at different altitudes result change in temperature which may affect the organs. To tackle such difficulties, in this work a smart container embedded with a Peltier module and a temperature sensor is developed to maintain the temperature thereby providing safety for healthcare products or organs. Further, the relay module and ESP8266 WIFI Microcontroller (MCU) is utilized to control the Peltier module which enables the user to send live data to the cloud, allowing the user to monitor and control the temperature remotely. The Blynk Internet of Things (IoT) platform is used to monitor the temperature of the smart medical container box. Results demonstrate that the proposed system is highly efficient on monitoring and controlling the smart medical container box temperature according to the set values. Also, the desired temperature range of the respective medical products or organs shall be maintained in an accurate manner. The drone equipped with smart medical container is tested in real time at different altitude levels to examine the performance of the developed system.