Reaction of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile with electrophilic agents

Aleksey Dolganov; Alexandra Chikava; Victor Dotsenko

doi:10.3390/ecsoc-27-16081

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Reaction of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile with electrophilic agents

Aleksey Dolganov

^*,

Alexandra Chikava

Victor Dotsenko

¹ Kuban state university
² ChemEx Lab, Vladimir Dal’ Lugansk National University
³ North Caucasus Federal University

Academic Editor: Julio A. Seijas

Published: 06 December 2023 by MDPI in The 27th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry

https://doi.org/10.3390/ecsoc-27-16081

Abstract:

1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile, prepared by the reaction of cyanoacetohydrazide with arylmethylene malononitriles, react with ninhydrin to give correspondingWith the formation of derivatives of dihydroindeno[1,2-e]pyrido[1,2-b][1,2,4]triazines. The reaction with glyoxal proceeds under mild conditions with the formation of 1,2,4-triazolo[1,5-a]pyridine.

Keywords: 1,6-diaminopyridines; cyanoacethydrazide; malononitrile

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Aleksey Dolganov

Alexandra Chikava

Victor Dotsenko