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Ugi-4CR/SN2-cyclization strategy for the one-pot synthesis of 2,5-diketopiperazines
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Academic Editor: Julio A. Seijas
Published:
15 November 2023
by MDPI
in The 27th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
2,5-diketopiperazines (2,5-DKPs) are the smallest cyclic peptides in nature and display a variety of bioactivities including antibacterial, antifungal, and anticancer, which are well documented pharmacophore. The one-pot synthesis of 2,5-DKPs is few reported. Herein, we report a novel one-pot synthesis of 2,5-DKPs via Ugi-4CR/SN2-cyclization strategy, under mild conditions, ethanol was used as a solvent for both procedures.
Keywords: 2,5-DKPs; IMCR; Ugi-4CR; bis-amide
