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Synthesis of mixed heterocycles from terephthalic acid
* 1 , 2 , 3
1  Laboratoire de Catalyse et synthèse en chimie organique, faculté des sciences, BP 119, 13000 Tlemcen, Algeria
2  Ecole Supérieure en Sciences Appliquées de Tlemcen (ESSAT), 13000 Tlemcen, Algeria
3  Faculté des Sciences, Université de Tlemcen, BP 119, 13000 Tlemcen, Algeria
Academic Editor: Julio A. Seijas (registering DOI)

The mixed heterocycles of the type Triazole, Thiadiazole, Oxazoles are very interesting chemical compounds in scientific research because of their potential of application in different fields, for this reason their synthesis has become a very important subject.

Our work aims to synthesize a new series of mixed heterocycles from terephthalic acid, which can be easily converted to monoalkyl terephthalate with good yields, via a two-step procedure. Treatment of monoalkyl terephthalate with SOCl2 provides methyl terephthalaoyl chloride, which reacts with thiosemicarbazide to give methyl 4-(2-carbamothioylhydrazine-1-carbonyl)benzoate, which is then used to synthesize the 1,2,4-triazole and 1,3,4-thiadiazole heterocycles.

Keywords: Terephtalic acid ; 1,2,4-triazole ; 1,3,4-thiadiazole ; mixed heterocycles.