The synthesis of α-hydroxyphosphonates and their derivatives attracted much attention due to their potential biological activities with broad applications as synthetic intermediates. They exhibit a variety of interesting and useful properties that make them attractive as herbicides, antibiotics, pesticides, antiviral and anticancer agents.

One of the current primary challenges is the development of synthetic methods that are environmentally friendly, aiming to design green chemical transformations and clean technologies. In this context, the utilization of microwave irradiation to expedite reactions has proven to be a particularly crucial tool in achieving the goals of green chemistry, which include waste minimization and reduced energy requirements.

In addition to the use of microwaves as a green method, Lewis catalysts have also piqued the interest of scientists due to their high utility in rapidly and selectively generating new products. Microwave activation, characterized by intense heating of the reaction combined with solid catalysis, offers advantages such as reusability, recoverability, and high selectivity, making it an excellent choice for synthetic methods.

As part of our research program aimed at developing highly efficient methods for synthesizing diverse phosphonate derivatives, our focus has centered on combining microwave irradiation with the utilization of the Lewis catalyst BiCl₃ to achieve a green synthesis of a series of α-hydroxyphosphonates.