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The Lithium-arene (cat.) System: New Applications to Organic Transformations
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1  Departamento de Quimica Organica, Universidad de Alicante, E-03080 Alicante, Spain.

Abstract: Epoxide 1 and benzamides 4 can be transformed, by means of an excess of lithium and a catalytic amount of an arene (naphthalene or DTBB) upon reaction of intermediates 2 and 5 with different electrophiles, into the D-glucose 3 and cyclohexadiene derivatives 6, respectively. The same couple lithium-arene in the presence of nickel chloride dihydrate can also be used in the reduction of halogenated compounds 7 to yield products 8.
Keywords: Anilines, chloroacetamides, sulfur, monothiooxamides, 2-carbamoylbenzothiazoles, thiooxanilic acids, benzothiazole-2-carboxylic acids.

 
 
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