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A new approach to synthesis of 2-carbamoylbenzothiazoles
Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: The reactions of substituted anilines with chloroacetamide and sulfur in the presence of triethylamine afford monothiooxamides, which being treated with K3Fe(CN)6 are cyclized to 2-carbamoylbenzothiazoles. The cyclization is established to be accompanied by the formation of the corresponding thiooxanilic acids, which are also cyclized to benzothiazole-2-carboxylic acids.
Keywords: Anilines, chloroacetamides, sulfur, monothiooxamides, 2-carbamoylbenzothiazoles, thiooxanilic acids, benzothiazole-2-carboxylic acids.