Pressurized Liquid Extraction (PLE) has become a pivotal technology for extracting secondary metabolites (e.g., phenolic compounds) from botanical sources, with implications spanning pharmaceuticals, nutraceuticals, and functional foods [1,2]. This communication provides an overview of recent advancements in understanding the key factors influencing the efficiency and selectivity of PLE in the extraction of these bioactive compounds. The optimization of PLE parameters, including pressure, temperature, and solvent characteristics, has been a focal point in recent research to enhance the extraction yield and preserve the integrity of secondary metabolites. Investigations into the interaction of sample matrix properties, particle size, and solvent polarity have revealed nuanced effects on the extraction process, contributing valuable insights to developing targeted extraction protocols. Also, technological innovations, such as the utilization of green solvents and novel extraction techniques, are reshaping the landscape of PLE. Different studies exploring sustainable approaches not only enhance extraction efficiency but also align with the growing emphasis on environmentally friendly practices, paving the way for greener extraction processes. Collaborative efforts among researchers have led to a deeper understanding of the factors influencing PLE. Thus, this abstract highlight recent progress in unraveling the complexities of PLE for secondary metabolites, fostering a foundation for optimizing extraction methodologies and leveraging these bioactive compounds for diverse applications.