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Monometallic and Bimetallic Platinum-containing nanoclusters for biomedical applications
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1  Department of Experimental Physics, Palacky University Olomouc
Academic Editor: Antonio Concilio


Nanosized materials with small diameters are known to be excellent for various applications such as catalysis, the sensing of biologically active species, and imaging, or for their anti-oxidant and anti-bacterial activity [1]. Noble metal nanoclusters (NCs) consisting of several atoms have been gaining much attention as novel fluorescent markers owing to their optical properties, which include their size-dependent emission wavelength. In the present study, we use the green synthesis of monometallic and bimetallic nanostructures with bovine serum albumin serving as a template, similarly to one of our previous works [2]. We have investigate the behavior of platinum-containing nanosystems generated by different reducing agents, varying the reactant molar ratios, varying the synthesis approach, and introducing the second metal. Pt NCs show fluorescence emission peak in the range of 450-470nm (370 nm excitation wavelength). Different molar ratios of the reactants have been used to optimize the fluorescent properties of monometallic and bimetallic Pt-containing NCs. The change in the reactants' molar ratios affected the fluorescence intensity and position of the fluorescence emission maximum. Other factors affecting the fluorescent characteristics of these metallic NCs are still under investigation. The as-prepared luminescent NCs can be utilized as contrast agents and/or biomarkers, which is going to be tested in the near future. Moreover, they could play a role in catalytic activity and biosensing, as known from the literature [3].


[1] Huang, X., Li, Z., Yu, Z., Deng, X., & Xin, Y. (2019). Recent advances in the synthesis, properties, and biological applications of platinum nanoclusters. Journal of Nanomaterials, 2019.

[2] Ostruszka, R., Půlpánová, D., Pluháček, T., Tomanec, O., Novák, P., Jirák, D., & Šišková, K. (2023). Facile One-Pot Green Synthesis of Magneto-Luminescent Bimetallic Nanocomposites with Potential as Dual Imaging Agent. Nanomaterials, 13(6), 1027.

[3] Xu, N., Li, H. W., Yue, Y., & Wu, Y. (2016). Synthesis of bovine serum albumin-protected high fluorescence Pt16-nanoclusters and their application to detect sulfide ions in solutions. Nanotechnology, 27(42), 425602.

Keywords: Biomaterials; Nanoclusters; Bioimaging