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Steroidal Tetraoxanes - New Class of Antitumor Compounds
Published: 01 November 1999 by MDPI in The 3rd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis
Abstract: Cholic acid derived steroidal tetraoxanes possessing methyl ester, carboxylic acid, primary and secondary amide termini were synthesised and their in vitro antitumor activity against Fem-X and HeLa cell cultures was determined. IC50 range between 3.1 and 166 M. Five out of seven tested compounds exhibited cell rounding and / or apoptic activity. Their liquid secondary ionization (LSI) and electronspray ionization (ESI) spectra confirmed the tetraoxane structure.
Keywords: Steroids, cholic acid, tetraoxanes, LSIMS, ESI, antitumor activity