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Steroidal Tetraoxanes - New Class of Antitumor Compounds
1 , 2 , 3 , * 4
1  Institute of Chemistry, Technology and Metallurgy, Belgrade
2  Centro Internazionale di Servizi di Spettrometria di Massa del C.N.R, Naples
3  Institute for Oncology and Radiology of Serbia, Belgrade
4  Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box 158, YU-11001 Belgrade, Yugoslavia

Abstract: Cholic acid derived steroidal tetraoxanes possessing methyl ester, carboxylic acid, primary and secondary amide termini were synthesised and their in vitro antitumor activity against Fem-X and HeLa cell cultures was determined. IC50 range between 3.1 and 166 M. Five out of seven tested compounds exhibited cell rounding and / or apoptic activity. Their liquid secondary ionization (LSI) and electronspray ionization (ESI) spectra confirmed the tetraoxane structure.
Keywords: Steroids, cholic acid, tetraoxanes, LSIMS, ESI, antitumor activity