Steroidal Tetraoxanes - New Class of Antitumor Compounds

Dejan Opsenica; Gabriela Pocsfalvi; Zorica Juranic; Bogdan Solaja

doi:10.3390/ecsoc-3-01769

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Steroidal Tetraoxanes - New Class of Antitumor Compounds

Dejan Opsenica

¹,

Gabriela Pocsfalvi

²,

Zorica Juranic

³,

Bogdan Solaja

^{*

4}

¹ Institute of Chemistry, Technology and Metallurgy, Belgrade
² Centro Internazionale di Servizi di Spettrometria di Massa del C.N.R, Naples
³ Institute for Oncology and Radiology of Serbia, Belgrade
⁴ Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box 158, YU-11001 Belgrade, Yugoslavia

Published: 01 November 1999 by MDPI in The 3rd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis

https://doi.org/10.3390/ecsoc-3-01769

Abstract: Cholic acid derived steroidal tetraoxanes possessing methyl ester, carboxylic acid, primary and secondary amide termini were synthesised and their in vitro antitumor activity against Fem-X and HeLa cell cultures was determined. IC50 range between 3.1 and 166 M. Five out of seven tested compounds exhibited cell rounding and / or apoptic activity. Their liquid secondary ionization (LSI) and electronspray ionization (ESI) spectra confirmed the tetraoxane structure.

Keywords: Steroids, cholic acid, tetraoxanes, LSIMS, ESI, antitumor activity

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Dejan Opsenica

Gabriela Pocsfalvi

Zorica Juranic

Bogdan Solaja