Please login first
Novel Thiophene-Derived Schiff Base as a Fluorescent Sensor for the Highly Sensitive and Selective Relay Recognition of Zn2+ and Fe2+ ions
* 1, 2, 2 , 3 , 1
1  Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P.119, Tlemcen 13000, Algeria.
2  Faculté de Médecine, Université de Tlemcen, 12 B P 123 Hamri Ahmed, Tlemcen 13000, Algeria.
3  1Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P.119, Tlemcen 13000, Algeria.
Academic Editor: Jun-Jie Zhu

Abstract:

Abstract:

Chemosensors based on Schiff bases are pivotal in environmental and biological applications, serving to identify specific metal ions at trace levels. Despite the distinctive importance of thiophene-based molecules in medicinal contexts, the number of reported chemosensors utilizing these moieties remains limited.

In this study, we present the synthesis and characterization of a novel Schiff base sensor (TBH), derived from thiophene-2-carboxaldehyde and benzil. We investigate its application as a selective relay probe for the detection of Zn2+ and Fe2+ ions.

The introduction of Zn2+ to TBH resulted in a significant enhancement in fluorescent intensity, attributed to the formation of a 1:1 TBH–Zn2+ complex, with no response observed for other cations, including Mg2+, Ba2+, Cd2+, Cu2+, Co2+, Mn2+, Cr3+, Hg2+, Sn2+, La3+, Ca2+, Na+, K+, and particularly Fe2+. Furthermore, Fe2+ induced fluorescence quenching in the TBH–Zn2+ system, forming a 1:1 MY–Fe2+ complex. The TBH-Zn2+ complex demonstrates potential as a secondary sensor for Fe2+ ions. The sensor's signal change is based on the chelation-enhanced fluorescence (CHEF) effect of TBH–Zn2+, coupled with the inhibition of photoinduced electron transfer (PET).

Moreover, the rapid and selective features of the proposed sensor make it promising for the precise monitoring of Zn2+and Fe2+ in biological and environmental research.

Keywords: Schiff-base Derivatives, Thiophene, Fluorescent chemosensor, Ion Detection.

 
 
Top