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Preparation of new enantiopure atropisomeric b-aminoalcohols and their use in asymmetric catalysis: enantioselective addition of diethylzinc to aromatic aldehydes.
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1  Dipartimento di Chimica, Università degli Studi della Basilicata, Via N. Sauro 85, 85100 Potenza, Italy.

Abstract: A new class of enantiopure b-aminoalcohols having 1,1’-binaphthyl skeleton, and chiral only by atropisomerism, has been prepared and tested as catalytic precursors in the asymmetric addition of diethylzinc to aromatic aldehydes. The aldehydes were quickly and cleanly (99% yield) transformed in the corresponding alcohols with ee up to 87%.
Keywords: b-aminoalcohols, atropisomerism, 1,1’-binaphthyls, diethylzinc.