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Synthesis of Enantiomerically Pure Pipecolic Acid Derivatives via Combination of Biocatalysis and Transition Metal Catalysis
1 , 1 , 1 , 2 , 1 , * 1, 3
1  Institute of Molecular Chemistry,University of Amsterdam Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands
2  DSM Research, Life Science Products P.O. Box 18, 6160 MD Geleen, The Netherlands
3  Department of Organic Chemistry, University of Nijmegen Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

Abstract: The combination of biocatalysis and transition metal catalysis provides a powerful and versatile pathway for the synthesis of multifunctional building blocks. In this approach, the biocatalyst is used to generate enantiomerically pure starting materials, while transition metals are used in a catalytic fashion for further synthetic elaboration.
Keywords: n/a