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Microwave-mediated Regioselective Synthesis of Novel Pyrimido[1,2-a]pyrimidines under Solvent-free Conditions
Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: In recent years there has been increasing interest in the design of alkyl 1,4-dihydropyrimidine-5-carboxylates (1,4-DHPMs) and related Biginelli-like compounds  which are presented as valuable substitutes  for the well known Nifedipine® and other 1,4-dihydropyridine drugs  clinically used in the treatment of cardiovascular diseases. That interest is illustrated, i.a., by the disclosure of elegant protocols involving solid phase synthesis approaches  as well as solvent-free preparations under microwave irradiation.  The purpose of the present work is to extend the scope of those studies to 2-amino derivatives and especially to the evaluation of their synthetic potential for the construction of novel pyrimido[1,2-a]pyrimidines, a ring system that can be found in marine-derived natural products such as crambescidin  and batzelladine  alkaloids.