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First Pd(0)-Catalyzed (Allylic Alkylation / Heck) Domino Sequence
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Abstract: The research in the field of domino reactions is attracting considerable attention in synthetic organic chemistry since it enables the rapid assembly of complex molecules in one-pot processes.2 In this contest, very elegant examples have been reported in the literature dealing with palladium-catalyzed cascade processes where a single catalytic cycle entails several sequential bond transformations.3 On the other hand, the development of multistep palladium-catalyzed processes belonging to multiple sequential, but discrete, catalytic cycles, albeit synthetically interesting and mechanistically intriguing, has been so far virtually unexplored.
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