Synthesis of Homochiral R-(+)-2-Methyl-1-butanol

Thomas Logothetis; Robert Vleggaar

doi:10.3390/ecsoc-4-01867

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Stable Carbonyl O-oxides and Dioxiranes

Synthesis of Homochiral R-(+)-2-Methyl-1-butanol

Thomas A. Logothetis

Robert Vleggaar

¹ Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-4-01867

Abstract: R-(+)-2-Methylbutanol 10a, a building block of several natural products, is commercially unavailable. The total synthesis of 10a in four steps utilising the boronic ester homologation approach is described.

Keywords: boron, stereoselective synthesis, homologation, boronic esters, 2-methylbutanol

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Thomas Logothetis

Robert Vleggaar