Background: Wound management is crucial in healthcare with effective, natural healing agents. Lantana montevidensis is known for its pharmacological properties, particularly in wound healing. This involves creating an extract from L. montevidensis flowers using water as solvent and putting it into a biocompatible matrix to form a patch.

Aim and Objective: This study aims to formulate a herbal wound healing patch using a Lantana montevidensis extract and evaluate its efficacy in promoting wound healing through in vitro studies.

Methodology: Herbal wound healing patches were prepared using the solvent casting method, with starch, sodium alginate, and glycerin as plasticizers. The plant extract was obtained by decoction, with water as the solvent. The patches' mechanical strength was assessed via folding endurance tests, and their compatibility was evaluated via an FTIR spectral analysis. In vitro evaluations included anti-inflammatory, antimicrobial, and hemocompatibility assessments, with stability tests conducted at accelerated temperatures.

Results and Discussion: The chemical analysis revealed the yield of active constituents. The IR spectral analysis identified no incompatibility in the distinctive wavenumber regions of the starch and sodium alginate films. The patches' swelling index and stability at room temperature were investigated. Their biocompatibility was confirmed via hemolysis ratio and pH measurements. The albumin denaturation inhibition of the herbal patches was assessed, indicating their potential wound healing properties.

Conclusion: The herbal wound healing patch developed using an L. montevidensis flower extract demonstrated promising efficacy in wound healing, suggesting its potential as natural remedy in wound management.