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Nitrobenzenesulfonylated Amide Linkers on Solid Support: Useful Starting Materials for Diversity Generation
* 1 , 2
1  Pharmacia&Upjohn, Discovery Research Oncology, Via Pasteur 10, I-20014 Nerviano, Italy
2  Novartis Pharma AG - Core Technology Area - CH-4002 Basel, Switzerland

Abstract: The Rink-linker (1a) [1] and analogous linkers like 1b [2] and 1c [3] are commonly used not only in peptide chemistry, but also in combinatorial chemistry, for grafting components with a carboxylic group onto the solid phase. Once assembled, the synthesis products are released into solution as carboxamides by acid treatment.
Keywords: n/a