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One pot Synthesis of Propargylamines using Solid-Phase Extractive Isolation
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1  F. Hoffmann-La Roche AG, Pharmaceuticals Research, CH-4070 Basel, Switzerland

Abstract: A library of 42 diverse propargylamines was prepared using a parallel solution phase synthesis approach. The compounds resulting from the Mannich reaction of acetylenes, paraformaldehyde and secondary amines in the presence of copper(I)-chloride were purified by Solid Phase Extraction.
Keywords: propargylamines, Mannich reaction, library, Solid Phase Extraction