One pot Synthesis of Propargylamines using Solid-Phase Extractive Isolation

Fabienne Fredon; Alexander Alanine; Guido Galley

doi:10.3390/ecsoc-4-01886

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One pot Synthesis of Propargylamines using Solid-Phase Extractive Isolation

Fabienne Fredon

Alexander Alanine

Guido Galley

¹ F. Hoffmann-La Roche AG, Pharmaceuticals Research, CH-4070 Basel, Switzerland

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session Solid Phase Chemistry and Combinatorial Synthesis

https://doi.org/10.3390/ecsoc-4-01886

Abstract: A library of 42 diverse propargylamines was prepared using a parallel solution phase synthesis approach. The compounds resulting from the Mannich reaction of acetylenes, paraformaldehyde and secondary amines in the presence of copper(I)-chloride were purified by Solid Phase Extraction.

Keywords: propargylamines, Mannich reaction, library, Solid Phase Extraction

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Fabienne Fredon

Alexander Alanine

Guido Galley