Native potatoes (Solanaceae) are an important Andean crop due to their excellent culinary quality, good flavor, and floury texture. They also contain vitamins, protein, minerals, and carbohydrates. In Peru, it is possible to observe an abundant morphological diversity of native potatoes grown in the Andean region. Native potatoes are cultivated and conserved mainly by old peasants in the highlands of the geographical department of Amazonas in Peru. However, this crop is disappearing due to the lack of knowledge of many farmers, limited studies on native potatoes, and climate change. To close this gap, as a first step, collecting trips in potato-producing localities in the geographical department of Amazonas were conducted in 2023 and 2024. These expeditions resulted in the collection of 96 native potato accessions as tubers from three provinces and 10 districts from Amazonas. This genetic material is currently under a regeneration process in the greenhouse of UNTRM. Then, DNA will be extracted from young fresh tissue and these will be shipped for whole-genome sequencing. A morpho-agronomic evaluation of this germplasm will be conducted in two locations in the present growing season, and a new cycle of evaluation will be performed in the following season. Genetic diversity parameters and population structures will be estimated from an SNP panel, and together with the morpho-agronomic data, a genome-wide association analysis will be carried out. This is the first comprehensive expedition of potatoes in the Amazonas. In the near future, genomic prediction models will be evaluated for enhancing the selection of accessions within this UNTRM potato germplasm, incorporating top genotypes into breeding programs. We expect that these efforts will stimulate additional work on potatoes in other geographical departments in the Peruvian Andes, alleviating poverty in rural areas.