Aromatic Iodination Method with Iodic Acid Used as the Iodinating Reagent

Barbara Krassowska-Swiebocka; Grazyna Prokopienko; Lech Skulski

doi:10.3390/ecsoc-8-01957

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Oxidative Iodination of Various Deactivated Arenes with I2 or KI in Concentrated Sulfuric Acid, and with Sodium Periodate Added as the Oxidant

Aromatic Iodination Method with Iodic Acid Used as the Iodinating Reagent

Barbara Krassowska-Swiebocka

Grazyna Prokopienko

Lech Skulski

¹ Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, 1 Banacha Street, PL 02-097 Warsaw, Poland

Published: 01 November 2004 by MDPI in The 8th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-8-01957

Abstract: Benzene, halobenzenes, and a number of more or less deactivated arenes, including nitrobenzene, readily reacted in anhydrous HIO3/AcOH/Ac2O/concd H2SO4 mixtures to probably give ArIO2 intermediates or other hypervalent species (not isolated). The final reaction mixtures were poured into excess aq. Na2SO3 solution (a reductor) to give the purified iodinated products in 39-83% yields.

Keywords: arenes; iodoarenes; aromatic iodination; iodic acid as reactant and iodinating agent

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Barbara Krassowska-Swiebocka

Grazyna Prokopienko

Lech Skulski