Please login first
A New Approach to 5-Functionalized Pyrimidine-2-Thiones
* , ,
1  Department of Organic Chemistry, State Academy of Fine Chemical Technology, Vernadsky Avenue 86, Moscow 117571, Russia.

Abstract: A new general convenient approach to the synthesis of pyrimidine-2-thiones/ones has been developed. This approach is based on the preparation of a-tosyl and a-azido substituted thioureas and ureas followed by the reaction with sodium enolates of carbonyl compounds.
Keywords: Thioureas, ureas, aldehydes, p-toluenesulfinic acid, hydrazoic acid, amidoalkylation, C-H acids, hexahydropyrimidine-2-thiones/ones, 1,2,3,4-tetrahydropyrimidine-2-thiones/ones.